Characteristics of Gestational Trophoblastic Disease at Prof. Dr. I.G.N.G. Ngoerah Hospital, Denpasar from 1st January 2020 to 31st December 2021

I Nyoman Gede Budiana; I Wayan Megadhana; Anak Agung Gede  Putra Wiradnyana; Gde Bagus Rizky Kornia

doi:10.24018/ejmed.2023.5.5.1584

Research Article

I Nyoman Gede Budiana

Udayana University, Indonesia

* Corresponding author

I Wayan Megadhana

Udayana University, Indonesia

Anak Agung Gede Putra Wiradnyana

Udayana University, Indonesia

Gde Bagus Rizky Kornia

Udayana University, Indonesia

10.24018/ejmed.2023.5.5.1584

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Submitted 2022-11-06
Published 2023-09-22

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Abstract

GTD is a rare abnormal condition of pregnancy, where the condition occurs when trophoblast cells proliferate uncontrollably so that it develops into an abnormal pregnancy. Abnormal pregnancy can lead to various negative effects such as vaginal bleeding, shortness of breath, and others. The high incidence of GTD is still not well documented to date. It is important to manage GTD appropriately to minimize acute complications and identify gestational trophoblastic tumor promptly. In this study, studyers took data from the oncogynecology register book regarding GTD and then presented it as descriptive data so that descriptive data analysis was carried out in the form of tables and narratives. The results of this study showed that GTD was highest in the age range of 31-35 years, parity 2, clinical symptoms of vaginal bleeding, previous pregnancy history with hydatidiform mole, gestational interval of 4 months or less, β-HCG level more than 100.000 mIU/ml, no metastases, histopathology of complete hydatidiform mole, stage I GTD, and receiving metrotrexate chemotherapy.

Keywords: abnormal pregnancy gestational trophoblastic disease oncogynecology

References

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Characteristics of Gestational Trophoblastic Disease at Prof. Dr. I.G.N.G. Ngoerah Hospital, Denpasar from 1st January 2020 to 31st December 2021. (2023). European Journal of Medical and Health Sciences, 5(5), 42-45. https://doi.org/10.24018/ejmed.2023.5.5.1584

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Vol. 5 No. 5 (2023)

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[1] Guo N, Yin R, Li Q, Song L, Wang D. Postmenopausal choriocarcinoma: a rare case report and review of the literature. Menopause. 2018;25(2):239-241. doi:10.1097/GME.0000000000000968.
DOI | Google Scholar

[2] Hui P. Gestational Trophoblastic Tumors: A Timely Review of Diagnostic Pathology. Arch Pathol Lab Med. 2019;143(1):65-74. doi:10.5858/arpa.2018-0234-RA.
DOI | Google Scholar

[3] Mao TL, Shih IeM. Advances in the diagnosis of gestational trophoblastic tumors and tumor-like lesions. Expert Opin Med Diagn. 2009;3(4):371-380. doi:10.1517/17530050903032646.
DOI | Google Scholar

[4] Savage J, Adams E, Veras E, Murphy KM, Ronnett BM. Choriocarcinoma in women: Analysis of a case series with genotyping. Am J Surg Pathol. 2017;41(12):1593-1606. doi:10.1097/PAS.0000000000000937.
DOI | Google Scholar

[5] Seckl MJ, Sebire NJ, Fisher RA, Golfier F, Massuger L, and Sessa C. Gestational trophoblastic disease: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013;24 Suppl 6:vi39-vi50. doi:10.1093/annonc/mdt345.
DOI | Google Scholar

[6] Pires KSN, Sun SY, Gonçalves CM, Santos JC, Tenorio LPG, Botelho RM, et al. Versican silencing in BeWo cells and its implication in gestational trophoblastic diseases. Histochem Cell Biol. 2019;151(4):305-313. doi:10.1007/s00418-018-1739-9.
DOI | Google Scholar

[7] Shu H, Chen H, Yang B, Chang Z, Xiong M, Chen W. Aberrant expression of E-cadherin and integrin β-1 in trophoblasts is associated with malignant gestational trophoblastic diseases. Int J Gynecol Cancer. 2013;23(4):749-754. doi:10.1097/IGC.0b013e31827da23f.
DOI | Google Scholar

[8] Li J, Yue H, Wang X, Chen R, Lu X. Chemotherapy for gestational trophoblastic neoplasia patients with a FIGO score of 12 or greater: A multistudy analysis. Eur J Obstet Gynecol Reprod Biol. 2019;238:164-169. doi:10.1016/j.ejogrb.2019.05.023.
DOI | Google Scholar

[9] Osborne R, Dodge J. Gestational trophoblastic neoplasia. Obstet Gynecol Clin North Am. 2012;39(2):195-212. doi:10.1016/j.ogc.2012.03.002.
DOI | Google Scholar

[10] Froeling FE, Seckl MJ. Gestational trophoblastic tumours: an update for 2014. Curr Oncol Rep. 2014;16(11):408. doi:10.1007/s11912-014-0408-y.
DOI | Google Scholar

[11] Ghorani E, Kaur B, Fisher RA, Short D, Joneborg U, Carlson JW, et al. Pembrolizumab is effective for drug-resistant gestational trophoblastic neoplasia. Lancet. 2017;390(10110):2343-2345. doi:10.1016/S0140-6736(17)32894-5.
DOI | Google Scholar

[12] You B, Bolze PA, Lotz JP, Massardier J, Gladieff L, Joly F, et al. Avelumab in patients with gestational trophoblastic tumors with resistance to single-agent chemotherapy: cohort A of the TROPHIMMUN phase II trial, J Clin Oncol. 2020;38 (27):3129–3137. doi:10.1200/JCO.20.00803.
DOI | Google Scholar

[13] Yang J, Zong L, Wang J, Wan X, Feng F, Xiang Y. Epithelioid trophoblastic tumors: Treatments, outcomes, and potential therapeutic targets. J Cancer. 2019;10(1):11-19. Published 2019 Jan 1. doi:10.7150/jca.28134.
DOI | Google Scholar

[14] Freitas F, Braga A, Viggiano M, Coca Velarde LG, Maesta I, Uberti E, et al. Gestational trophoblastic neoplasia lethality among Brazilian women: A retrospective national cohort study. Gynecol Oncol. 2020;158(2):452-459. doi:10.1016/j.ygyno.2020.04.704.
DOI | Google Scholar

Characteristics of Gestational Trophoblastic Disease at Prof. Dr. I.G.N.G. Ngoerah Hospital, Denpasar from 1st January 2020 to 31st December 2021

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