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Precocious puberty is a multifactorial process whose diagnosis is based, first of all, on the clinic but also on the realization of the bone age, the pelvic ultrasound and the cerebral IRM. Moreover, the GnRH test constitutes the cornerstone to highlight a premature activation of the Hypothalamo-hypophyseal axis. We report the case of a 3-year-old girl admitted for exploration of precocious puberty. The central origin was confirmed by a GnRH test with a peak reaching 45 mIU/L. A hypothalamohypophyseal MRI was performed, showing a mass consistent with a hypothalamic hamartoma. Treatment with GnRH analogues is the treatment of choice for central precocious puberty.

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References

  1. S. Benyakhlef, N. Messaoudi, S. Rouf, H. Latrech, “Hypothalamic hamartoma revealed by precocious puberty: about a case.” SFE Marseille 2020; Annales d'Endocrinologie ; 81 : 282-314.
     Google Scholar
  2. J. Mounacha, R. Abilkassem, A. Zerhouni, A. Satté, A. Bourazza, H. Baizri, H. Ouhabi, A. Agadr, “Precocious puberty due to hypothalamic hamartoma.” Archives of Pediatrics; 2010; 17:1095-1097.
     Google Scholar
  3. A. S. Harvey, J. L. Freeman, “Epilepsy in hypothalamic hamartoma: Clinical and EEG features.” Semin Pediatr Neurol; 2007; 14: 60-4.
     Google Scholar
  4. N. Ech-Cherif El Kettani, O. Mouti, H. Benchaaboun, M. Fikri, M-R El Hassani, M. Jiddane, “Hypothalamic hamartoma revealing gelastic seizures.” Archives of Pediatrics 2014; 21:529-531.
     Google Scholar
  5. Dorfmûller G, Fohlen M, Bulteau C, O. Delalande, “Surgical disconnection of hypothalamic hamartomas.” Neurosurgery 2008; 54:315-9.
     Google Scholar
  6. P. Pallavee, R. Samal, “Precocious puberty: a clinical review.” Int J Reprod Contracept Obstet Gynecol. 2018 Mar;7(3):771-777.
     Google Scholar
  7. I. R. Rousso, M. Kourti, D. Papandreou, A. Tragiannidis, F. Athanasiadou, “Central precocious puberty due to hypothalamic hamartoma in a 7-month-old infant girl.” Eur J Pediatr 2008; 167:583–585.
     Google Scholar