Synchronous Association of Squamous Cell Carcinoma of the Larynx and Clear Cell Renal Cell Carcinoma:  A Case Report

Mohamed Chehbouni; Othmane Benhoummad

doi:10.24018/ejmed.2021.3.3.903

Case Study

Mohamed Chehbouni

Provincial Hospital Mokhtar Soussi, Morocco

* Corresponding author

Othmane Benhoummad

Ibn Zohr University, Morocco

10.24018/ejmed.2021.3.3.903

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Submitted 2021-05-31
Published 2021-06-23

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Abstract

Laryngeal squamous cell carcinomas represent the most frequent form (over 90%) of laryngeal cancer, but their association with renal tumors is rare; the literature most often reports the synchronous association of carcinoma of the larynx with carcinoma of the upper aerodigestive tract or with bronchial carcinoma. We report the case of a 60-year-old patient, who is followed for a clear cell carcinoma of the kidney, and in whom we made the diagnosis of a squamous cell carcinoma of the larynx. We illustrate through this observation the rarity and the epidemiological profile of this presentation with a broad review of the literature.

Keywords: synchronous tumors, multiple primary malignant tumors, laryngeal cancer, renal tumors

References

Brown, M. Second primaries in cases of cancer of the larynx. J. Laryngol. Otol. 92, 991–996 (1978).
Google Scholar

Moertel, C. Multiple primary malignant neoplasms. Introduction and presentation of data. Cancer, 14: 221-230 (1961).
Google Scholar

Warren, S. & Gates, O. Multiple primary malignant tumors: a survey of the literature and statistical study. Am J Cancer. 1358–1414 (1932).
Google Scholar

Detterbeck, F. C., Jones, D. R., Kernstine, K. H. & Naunheim, K. S. Special Treatment Issues*. Chest 123, 244S-258S (2003).
Google Scholar

Irimie, A., Achimas-Cadariu, P., Burz, C. & Puscas, E. Multiple Primary Malignancies – Epidemiological Analysis at a Single Tertiary Institution. 6.
Google Scholar

Ono, Y. et al. Autopsy findings of patients with urological neoplasms. Int J Clin Oncol 7, 0301–0305 (2002).
Google Scholar

Piccinini, L., Luppi, G., Zoboli, A. & Torricelli, P. Occasional Diagnosis of Synchronous Renal Cell Carcinoma during Staging of Other Primary Tumors. Tumori 82, 488–490 (1996).
Google Scholar

Miyahara, H., Tsuruta, Y., Umatani, K., Yoshino, K. & Sato, T. Multiple Primary Tumors in Patients With Head and Neck Cancer. Auris Nasus Larynx 12, S30–S35 (1985).
Google Scholar

Begg, C. B., Zhang, Z., Sun, M., Herr, H. W. & Schantz, S. P. Methodology for Evaluating the Incidence of Second Primary Cancers with Application to Smoking-relted Cancers from the Surveillance, Epidmiology, and End Results (SEER) Program. American Journal of Epidemiology 142, 653–665 (1995).
Google Scholar

Etiz, D., Metcalfe, E. & Akcay, M. Multiple primary malignant neoplasms: A 10-year experience at a single institution from Turkey. J Can Res Ther 13, 16 (2017).
Google Scholar

Mh, G., Rn, H. & Jr, F. J. Subsequent cancer in patients with chronic lymphocytic leukemia--a possible immunologic mechanism. J Natl Cancer Inst 61, 337–340 (1978).
Google Scholar

Khuri, F. R. et al. The Impact of Smoking Status, Disease Stage, and Index Tumor Site on Second Primary Tumor Incidence and Tumor Recurrence in the Head and Neck Retinoid Chemoprevention Trial. Cancer Epidemiol Biomarkers Prev 10, 823–829 (2001).
Google Scholar

Gallo, O. & Bianchi, S. p53 Expression: a potential biomarker for risk of multiple primary malignancies in the upper aerodigestive tract. European Journal of Cancer Part B: Oral Oncology 31, 53–57 (1995).
Google Scholar

Richard, S. Prédispositions héréditaires au cancer rénal. Actualités néphrologiques Jean Hamburger 131–150 (2006).
Google Scholar

Rae, F. K., Hooper, J. D., Nicol, D. L. & Clements, J. A. Characterization of a novel gene,STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors. Mol. Carcinog. 32, 44–53 (2001).
Google Scholar

Sarkis, P., Bou-Malhab, F. & Mouaccadieh, L. Métastase laryngée unique d’un carcinome rénal à cellules claires : cas clinique et revue de la littérature. Progrès en Urologie 22, 307–309 (2012).
Google Scholar

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Synchronous Association of Squamous Cell Carcinoma of the Larynx and Clear Cell Renal Cell Carcinoma: A Case Report. (2021). European Journal of Medical and Health Sciences, 3(3), 64-66. https://doi.org/10.24018/ejmed.2021.3.3.903

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Vol. 3 No. 3 (2021)

[1] Brown, M. Second primaries in cases of cancer of the larynx. J. Laryngol. Otol. 92, 991–996 (1978).
Google Scholar

[2] Moertel, C. Multiple primary malignant neoplasms. Introduction and presentation of data. Cancer, 14: 221-230 (1961).
Google Scholar

[3] Warren, S. & Gates, O. Multiple primary malignant tumors: a survey of the literature and statistical study. Am J Cancer. 1358–1414 (1932).
Google Scholar

[4] Detterbeck, F. C., Jones, D. R., Kernstine, K. H. & Naunheim, K. S. Special Treatment Issues*. Chest 123, 244S-258S (2003).
Google Scholar

[5] Irimie, A., Achimas-Cadariu, P., Burz, C. & Puscas, E. Multiple Primary Malignancies – Epidemiological Analysis at a Single Tertiary Institution. 6.
Google Scholar

[6] Ono, Y. et al. Autopsy findings of patients with urological neoplasms. Int J Clin Oncol 7, 0301–0305 (2002).
Google Scholar

[7] Piccinini, L., Luppi, G., Zoboli, A. & Torricelli, P. Occasional Diagnosis of Synchronous Renal Cell Carcinoma during Staging of Other Primary Tumors. Tumori 82, 488–490 (1996).
Google Scholar

[8] Miyahara, H., Tsuruta, Y., Umatani, K., Yoshino, K. & Sato, T. Multiple Primary Tumors in Patients With Head and Neck Cancer. Auris Nasus Larynx 12, S30–S35 (1985).
Google Scholar

[9] Begg, C. B., Zhang, Z., Sun, M., Herr, H. W. & Schantz, S. P. Methodology for Evaluating the Incidence of Second Primary Cancers with Application to Smoking-relted Cancers from the Surveillance, Epidmiology, and End Results (SEER) Program. American Journal of Epidemiology 142, 653–665 (1995).
Google Scholar

[10] Etiz, D., Metcalfe, E. & Akcay, M. Multiple primary malignant neoplasms: A 10-year experience at a single institution from Turkey. J Can Res Ther 13, 16 (2017).
Google Scholar

[11] Mh, G., Rn, H. & Jr, F. J. Subsequent cancer in patients with chronic lymphocytic leukemia--a possible immunologic mechanism. J Natl Cancer Inst 61, 337–340 (1978).
Google Scholar

[12] Khuri, F. R. et al. The Impact of Smoking Status, Disease Stage, and Index Tumor Site on Second Primary Tumor Incidence and Tumor Recurrence in the Head and Neck Retinoid Chemoprevention Trial. Cancer Epidemiol Biomarkers Prev 10, 823–829 (2001).
Google Scholar

[13] Gallo, O. & Bianchi, S. p53 Expression: a potential biomarker for risk of multiple primary malignancies in the upper aerodigestive tract. European Journal of Cancer Part B: Oral Oncology 31, 53–57 (1995).
Google Scholar

[14] Richard, S. Prédispositions héréditaires au cancer rénal. Actualités néphrologiques Jean Hamburger 131–150 (2006).
Google Scholar

[15] Rae, F. K., Hooper, J. D., Nicol, D. L. & Clements, J. A. Characterization of a novel gene,STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors. Mol. Carcinog. 32, 44–53 (2001).
Google Scholar

[16] Sarkis, P., Bou-Malhab, F. & Mouaccadieh, L. Métastase laryngée unique d’un carcinome rénal à cellules claires : cas clinique et revue de la littérature. Progrès en Urologie 22, 307–309 (2012).
Google Scholar

[17] Luciani, A. Multiple primary malignancies. Seminars in Oncology 31, 264–273 (2004).
Google Scholar

Synchronous Association of Squamous Cell Carcinoma of the Larynx and Clear Cell Renal Cell Carcinoma: A Case Report

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