Crisis Center "Dream", Ukraine
* Corresponding author

Article Main Content

Nonconvulsive epileptic seizures are major type of seizures of all patients with predominantly focal epilepsy. However, this problem is still insufficiently studied, the literature presents a few data on the diagnosis and treatment of nonconvulsive status epilepticus (NCSE). NCSE is a prolonged seizure, not accompanied by severe motor presentation. Such attacks occur much more often than previously thought. NCSE is divided into focal NCSE (complex partial status epilepticus), and generalized NCSE, often referred as absence status. The absence status divides into a typical absence status (presents with suppression of consciousness of various depths, myoclonic twitching of the eyelids, impoverishment of speech production and hallucinations), atypical absence status (presents with retardation of mental processes and eyelid myoclonus) and late absence status (long-term disorientation accompanied by cognitive deficiency and presents mainly in elderly patients). According to the available sources, more than 30% of patients in the intensive care units with impaired consciousness of unclear genesis are patients with NCSE. Use of antiepileptic drugs for intravenous administration opens better opportunities in the treatment of patients with status epilepticus and NCSE.

References

  1. Sirven, J. I., & Waterhouse, E. (2003). Management of status epilepticus. American family physician, 68(3), 469-476.
     Google Scholar
  2. Towne, A. R., Waterhouse, E. J., Boggs, J. G., Garnett, L. K., Brown, A. J., Smith, J., & DeLorenzo, R. J. (2000). Prevalence of nonconvulsive status epilepticus in comatose patients. Neurology, 54(2), 340-340.
     Google Scholar
  3. Jordan, K. G., & Hirsch, L. J. (2006). In Nonconvulsive Status Epilepticus (NCSE), Treat to Burst‐Suppression: Pro and Con. Epilepsia, 47, 41-45.
    DOI  |   Google Scholar
  4. Jordan, K. G. (1992). Nonconvulsive seizures (NCS) and nonconvulsive status epilepticus (NCSE) detected by continuous monitoring in the Neuro ICU (NICU-CEEG). Neurology, 42(13), 194.
     Google Scholar
  5. Towne, A. R., Waterhouse, E. J., Boggs, J. G., Garnett, L. K., Brown, A. J., Smith, J., & DeLorenzo, R. J. (2000). Prevalence of nonconvulsive status epilepticus in comatose patients. Neurology, 54(2), 340-340.
    DOI  |   Google Scholar
  6. Tsarkov, A., & Petlovanyi, P. (2019). Neuropsychiatric Aspects of a Common Problem: Stroke. European Journal of Medical and Health Sciences, 1(3).
    DOI  |   Google Scholar
  7. DeLorenzo, R. J., Waterhouse, E. J., Towne, A. R., Boggs, J. G., Ko, D., DeLorenzo, G. A., ... & Garnett, L. (1998). Persistent nonconvulsive status epilepticus after the control of convulsive status epilepticus. Epilepsia, 39(8), 833-840.
    DOI  |   Google Scholar
  8. Privitera, M., Hoffman, M., Moore, J. L., & Jester, D. (1994). EEG detection of nontonic-clonic status epilepticus in patients with altered consciousness. Epilepsy research, 18(2), 155-166.
    DOI  |   Google Scholar
  9. Vespa, P. M., Nuwer, M. R., Nenov, V., Ronne-Engstrom, E., Hovda, D. A., Bergsneider, M., ... & Becker, D. P. (1999). Increased incidence and impact of nonconvulsive and convulsive seizures after traumatic brain injury as detected by continuous electroencephalographic monitoring. Journal of neurosurgery, 91(5), 750-760.
    DOI  |   Google Scholar
  10. Vespa, P. M., O’phelan, K., Shah, M., Mirabelli, J., Starkman, S., Kidwell, C., ... & Martin, N. A. (2003). Acute seizures after intracerebral hemorrhage: a factor in progressive midline shift and outcome. Neurology, 60(9), 1441-1446.
    DOI  |   Google Scholar
  11. Schwab, R. S. (1953). A case of status epilepticus in petit mal. Electroencephalography and clinical neurophysiology, 5(3), 441.
    DOI  |   Google Scholar
  12. Thomas, P., Beaumanoir, A., Genton, P., Dolisi, C., & Chatel, M. (1992). 'De novo'absence status of late onset: Report of 11 cases. Neurology, 42(1), 104-104.
    DOI  |   Google Scholar
  13. Kimura, S., & Kobayashi, T. (1996). Two patients with juvenile myoclonic epilepsy and nonconvulsive status epilepticus. Epilepsia, 37(3), 275-279.
    DOI  |   Google Scholar
  14. Engel, J., Ludwig, B. I., & Fetell, M. (1978). Prolonged partial complex status epilepticus: EEG and behavioral observations. Neurology, 28(9), 863-863.
    DOI  |   Google Scholar
  15. Drislane, F. W., & Schomer, D. L. (1994). Clinical implications of generalized electrographic status epilepticus. Epilepsy research, 19(2), 111-121.
    DOI  |   Google Scholar
  16. Tsarkov A, Msoni P and Petlovanyi P. (2020). Uncommon presentation: Folie à deux (Case study). World Journal of Advanced Research and Reviews, 6(3), 43-49.
     Google Scholar
  17. Anatolii, T., Patrick, M., & Petro, P. (2020). Uncommon presentation: Folie à deux (Case study). World Journal of Advanced Research and Reviews, 6(3), 043-049.
    DOI  |   Google Scholar
  18. Petlovanyi, P., & Tsarkov, A. Child Schizophrenia: Theory and Practice.
     Google Scholar
  19. Tsarkov, A., & Petlovanyi, P. (2016). Bipolar Disorder in Child Psychiatric Practice: A Case Report. Medical Journal of Zambia, 43(1), 41-46.
     Google Scholar
  20. Tsarkov, A., & Petlovanyi, P. (2016). Bipolar disorder in child psychiatric practice.
     Google Scholar
  21. Tsarkov, A., & Petlovanyi, P. The Role of Lamotrigine in the Treatment of Bipolar Depression.
     Google Scholar
  22. Bellesi, M., Passamonti, L., Silvestrini, M., Bartolini, M., & Provinciali, L. (2006). Non-convulsive status epilepticus during lithium treatment at therapeutic doses. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 26(6), 444–446.
    DOI  |   Google Scholar
  23. Lebedyn, Z. (2020). Antidepressants In General Practice And Psychiatry. European Journal of Medical and Health Sciences, 2(3). https://doi.org/10.24018/ejmed.2020.2.3.318.
     Google Scholar
  24. Lebedyn, Z. (2019). The Use of Antidepressants by General Practitioners and Psychiatrists ( Personal Experience ).
    DOI  |   Google Scholar
  25. Petlovanyi, P., & Tsarkov, A. (2017). Depressive Disorder in Child Psychiatric Practice: A Case Report. Health Press Zambia Bull, 1(5), 9.
     Google Scholar
  26. Tsarkov, A., & Petlovanyi, P. Depressive Disorder in Child Psychiatric Practice: A. The Health Press, 9.
     Google Scholar
  27. Reeve-Johnson, L., Unwin, A., & Mc Connell, H. (2014). Generalised Non-Convulsive Status Epilepticus (NCSE) following Electro-Convulsive Therapy. J Psychol Psychother, 4(138), 2161-0487.
     Google Scholar
  28. Krishnamoorthy, E. S., Trimble, M. R., & Blumer, D. (2007). The classification of neuropsychiatric disorders in epilepsy: a proposal by the ILAE Commission on Psychobiology of Epilepsy. Epilepsy & Behavior, 10(3), 349-353.
    DOI  |   Google Scholar
  29. López Arteaga, T., Amo, C., Serrano González, C., & Huertas Sánchez, D. (2013). Nonconvulsive status epilepticus and psychotic symptoms: case report. Rivista di psichiatria, 48(3), 268–270.
     Google Scholar
  30. Petlovanyi P and Tsarkov A. (2020). Practical guide and some recommendations for the diagnosis and management of Attention deficit hyperactivity disorder (ADHD). World Journal of Advanced Research and Reviews, 6(3), 257-261.
     Google Scholar
  31. Petro, P., & Anatolii, T. (2020). Practical guide and some recommendations for the diagnosis and management of Attention deficit hyperactivity disorder (ADHD). World Journal of Advanced Research and Reviews, 6(3), 257-261.
    DOI  |   Google Scholar
  32. Tsarkov, A., & Petlovanyi, P. (2017). Omega-3 Fatty Acids as an Alternative Treatment for Children with Attention Deficit Hyperactivity Disorder. Imperial Journal of Interdisciplinary Research (IJIR), 3, 1378-1380.
     Google Scholar
  33. Cohen, R., Senecky, Y., Shuper, A., Inbar, D., Chodick, G., Shalev, V., & Raz, R. (2013). Prevalence of epilepsy and attention-deficit hyperactivity (ADHD) disorder: a population-based study. Journal of child neurology, 28(1), 120-123.
    DOI  |   Google Scholar
  34. Tsarkov, A., & Petlovanyi, P. (2017). Pathological Gambling: The Old Problem of the Modern World. Imperial Journal of Interdisciplinary Research, 3(8), 216-221.
     Google Scholar
  35. Storrier, S., & Beran, R. G. (2014). Compulsive gambling possibly associated with antiepileptic medication. Epilepsy & behavior case reports, 2, 15–16.
    DOI  |   Google Scholar
  36. Nevitt, S. J., Marson, A. G., Weston, J., & Smith, C. T. (2018). Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review. Cochrane Database of Systematic Reviews, (8).
    DOI  |   Google Scholar
  37. Meierkord, H., Boon, P., Engelsen, B., Göcke, K., Shorvon, S., Tinuper, P., & Holtkamp, M. (2010). EFNS guideline on the management of status epilepticus in adults. European journal of neurology, 17(3), 348-355.
    DOI  |   Google Scholar
  38. Peters, C. N., & Pohlmann-Eden, B. (2005). Intravenous valproate as an innovative therapy in seizure emergency situations including status epilepticus—experience in 102 adult patients. Seizure, 14(3), 164-169.
    DOI  |   Google Scholar
  39. Stahl, S. M., & Stahl, S. M. (2013). Stahl's essential psychopharmacology: neuroscientific basis and practical applications. Cambridge university press.
     Google Scholar
  40. Fay, M. A., Sheth, R. D., & Gidal, B. E. (2005). Oral absorption kinetics of levetiracetam: the effect of mixing with food or enteral nutrition formulas. Clinical therapeutics, 27(5), 594-598.
    DOI  |   Google Scholar
  41. Patel, N. C., Landan, I. R., Levin, J., Szaflarski, J., & Wilner, A. N. (2006). The use of levetiracetam in refractory status epilepticus. Seizure, 15(3), 137-141.
    DOI  |   Google Scholar
  42. Pato-Pato, A., Rana-Martinez, N., Lorenzo-Gonzalez, J. R., & Cimas-Hernando, I. (2006). The value of an oral solution of levetiracetam in status epilepticus. Revista de neurologia, 42(12), 768-768.
    DOI  |   Google Scholar
  43. Novy, J., Logroscino, G., & Rossetti, A. O. (2010). Refractory status epilepticus: a prospective observational study. Epilepsia, 51(2), 251-256.
    DOI  |   Google Scholar
  44. Jacobsen, P. L., & Eden, O. (2008). Epilepsy and the dental management of the epileptic patient. J Contemp Dent Pract, 9(1), 54-62.
    DOI  |   Google Scholar
  45. Phiri, C., Tsarkov, A., Petlovanyi, P., & Lingenda, G. Factors Contributing To Oral Diseases and Treatment Needs amongst Mental Patients at Chainama Hills College Hospital, Lusaka, Zambia.
     Google Scholar
  46. Jo, S., & Bean, B. P. (2017). Lacosamide inhibition of Nav1. 7 voltage-gated sodium channels: slow binding to fast-inactivated states. Molecular pharmacology, 91(4), 277-286.
    DOI  |   Google Scholar
  47. Brigo, F. (2017). Lacosamide monotherapy for newly diagnosed epilepsy. The Lancet Neurology, 16(1), 20-22.
    DOI  |   Google Scholar
  48. Abou Khaled, K., Khoury, J., Macaron, G., & Richa, S. (2016). Forced normalization and psychosis following use of lacosamide. Seizure-European Journal of Epilepsy, 41, 96-99.
    DOI  |   Google Scholar