Laryngeal NK/T Cell Lymphoma, Nasal Type: Case Report and Literature Review
##plugins.themes.bootstrap3.article.main##
Extranodal Natural Killer T-cell lymphoma, nasal type represent a rare and aggressive entity of the non-Hodgkin's lymphomas. Laryngeal localization is rare and has a poor prognosis. We report the case of a 66-year-old patient who consulted for dyspnea, dysphonia and dysphagia. Endoscopic examination revealed an endo-laryngeal lesion. Anatomopathological study with immunohistochemistry concluded to a peripheral T NK/T-cell lymphoma nasal type. The extension workup was without abnormalities. Induction chemotherapy without anthracyclines was administered followed by conformal radiotherapy with intensity modulation in arctotherapy. Significant advances have been made over the past decade including better clarification of clinical heterogeneity, more accurate classification using imaging modalities, establishment of new prognostic models, and sequential use of anthracycline-free radiotherapy and chemotherapy in early stages and risk-adapted first-line treatment strategies in advanced stages.
Downloads
References
-
Swerdlow S, Campo E, Harris N, Jaffe E, Pileri S, Stein H, et al. World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th ed. Lyon; 2017.
Google Scholar
1
-
Galtier J, Parrens M, Milpied N. Lymphomes T périphériques: diagnostic et prise en charge [Peripheral T cell lymphomas: diagnosis and treatment]. Rev Med Interne. 2020; 41(12): 829-837. French.
Google Scholar
2
-
Ferlito A. The World Health Organization’s revised classification of tumours of the larynx, hypopharynx, and trachea. Ann Otol Rhinol Laryngol. 1993; 102: 666-669.
Google Scholar
3
-
McBride, P. Photographs of a case of rapid destruction of the nose and face. J. Laryngol. Otol. 1897; 12: 64-66.
Google Scholar
4
-
Su Y-J, Wang P-N, Chang H, Shih L-Y, Lin T-L, Kuo M-C, et al. Extranodal NK/T-cell lymphoma, nasal type: Clinical features, outcome, and prognostic factors in 101 cases. Eur. J. Haematol. 2018; 101: 379-388.
Google Scholar
5
-
Au WY, Ma SY, Chim CS, Choy C, Loong F, Lie AKW, et al. Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: A single center experience of 10 years. Ann. Oncol. 2005; 16: 206-214.
Google Scholar
6
-
Avilès A. Nasal NK/T-Cell lymphoma. A comparative analysis of a Mexican population with the other populations of Latin-America. Mediterr. J. Hematol. Infect. Dis. 2015; 7: e2015052.
Google Scholar
7
-
Gualco G, Domeny-Duarte P, Chioato L, Barber G, Natkunam Y, Bacchi CE. Clinicopathologic and molecular features of 122 Brazilian cases of nodal and extranodal NK/T-cell lymphoma, nasal type, with EBV subtyping analysis. Am. J. Surg. Pathol. 2011; 35: 1195-1203.
Google Scholar
8
-
Haverkos BM, Pan Z, Gru AA, Freud AG, Rabinovitch R, Xu-Welliver M, et al. Extranodal NK/T cell lymphoma, nasal type (ENKTL-NT): an update on epidemiology, clinical presentation, and natural history in north American and European cases. Curr. Hematol. Malig. Rep. 2016; 11: 514-527.
Google Scholar
9
-
Yang Q-P, Zhang W-Y, Yu J-B, Zhao S, Xu, H, Wang W-Y, et al. Subtype distribution of lymphomas in Southwest China: analysis of 6,382 cases using WHO classification in a single institution. Diagn. Pathol. 2011; 22(6): 77.
Google Scholar
10
-
Diallo M, Diop A, Diatta BA, Ndiaye M, Ortonne N, Dieng MT. Extranodal natural killer/T-cell lymphoma, nasal type, in Senegal. Int. J. Dermatol. 2018; 57: 401-405.
Google Scholar
11
-
Li YX, Fang H, Liu QF, Lu J, Qi SN, Wang H, et al. Clinical features and treatment outcome of nasal-type NK/T-cell lymphoma of Waldeyer ring. Blood. The Journal of the American Society of Hematology. 2008; 112(8): 3057-64.
Google Scholar
12
-
Ahn HK, Suh C, Chuang SS, Suzumiya J, Ko YH, Kim SJ, et al. Extranodal natural killer/T-cell lymphoma from skin or soft tissue: Suggestion of treatment from multinational retrospective analysis. Ann Oncol. 2012; 23: 2703-2707.
Google Scholar
13
-
Kim TM, Lee SY, Jeon YK, Ryoo BY, Cho GJ, Hong YS, et al. Clinical heterogeneity of extranodal NK/T cell lymphoma, nasal type: A national survey of the Korea Cancer Study Group. Ann Oncol. 2008; 19: 1477-1484.
Google Scholar
14
-
Sánchez-Romero C, Bologna-Molina R, Paes de Almeida O, Santos-Silva AR, Prado-Ribeiro AC, Brandão TB, et al. Extranodal NK/T cell lymphoma, nasal type: An updated overview. Crit Rev Oncol Hematol. 2021; 159: 103237.
Google Scholar
15
-
Al Shawabkeh MA, Al Sulaiti M, Al Sa’ey H, Ganesan S. Nasal type extranodal natural killer/T (NK/T) cell lymphoma presenting as periorbital cellulitis: a case report. Am. J. Case Rep. 2016; 17: 934-938.
Google Scholar
16
-
Hamzaoui M, Essid A, Sahli S, Ben Salah M, Boussen H, Ben Attia M, et al. Nasal angiocentric T cell-natural killer cell lymphoma with pancreatic localisation in a child. Arch Pediatr. 2003; 10: 979-982.
Google Scholar
17
-
Xiang C-X, Chen Z-H, Zhao S. Laryngeal extranodal nasal-type natural Killer/T-cell lymphoma a clinicopathologic study of 31 cases in China, Am. J. Surg. Patho. 2019; 43: 995-1004.
Google Scholar
18
-
Qi SN, Li YX, Specht L, Oguchi M, Tsang R, Ng A, et al. Modern radiation therapy for extranodal nasal type NK/T cell lymphoma: risk adapted therapy, target volume, and dose guidelines from the International Lymphoma Radiation Oncology Group. Int J Radiat Oncol Biol Phys. 2021; 110(4): 1064-81.
Google Scholar
19
-
Miyake MM, de, Oliveira MVC, Miyake MM, Garcia JO de A, Granato L. Clinical and otorhinolaryngological aspects of extranodal NK/T cell lymphoma, nasal type. Braz. J. Otorhinolaryngol. 2014; 80: 325-329.
Google Scholar
20
-
Pereira AAC, Ferreira CB, Hanemann JAC, Paranaiba LMR, Pereira PPI, Rodrigues-Fernandes CI, et al. Oral manifestation of lymphomatoid granulomatosis. Head Neck Pathol. 2019; 13: 270-276.
Google Scholar
21
-
Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, et al. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. J Clin Oncol. 2014; 32: 3059-3067.
Google Scholar
22
-
Tse E, Kwong YL. Nasal NK/T cell lymphoma: RT, CT, or both. Blood. 2015; 126(12): 1400-1401.
Google Scholar
23
-
Kwong YL, Anderson BO, Advani R, Kim WS, Levine AM, Lim ST. Asian Oncology Summit. Management of T cell and natural killer cell neoplasms in Asia: consensus statement from the Asian Oncology Summit 2009. Lancet Oncol. 2009; 10(11): 1093-101.
Google Scholar
24
-
Tse E, Kwong YL. The diagnosis and management of NK/T cell lymphomas. J Hematol Oncol. 2017; 10(1): 85.
Google Scholar
25
-
Yamaguchi M, Kita K, Miwa H, Nishii K, Oka K, Ohno T, et al. Frequent expression of P glycoprotein/MDR1 by nasal T cell lymphoma cells. Cancer. 1995; 76(11): 2351-2356.
Google Scholar
26
-
Qi SN, Yang Y, Song YQ, Wang Y, He X, Hu C, et al. First line non-anthracycline based chemotherapy for extranodal nasal type NK/T cell lymphoma: a retrospective analysis from the CLCG. Blood Adv. 2020; 4(13): 3141-3153.
Google Scholar
27
-
Tse E, Zhao WL, Xiong J, Kwong YL. How we treat NK/T-cell lymphomas. J Hematol Oncol. 2022; 15(1): 74.
Google Scholar
28
-
Ando M, Sugimoto K, Kitoh T, Sasaki M, Mukai K, Ando J, et al. Selective apoptosis of natural killer cell tumours by l asparaginase. Br J Haematol. 2005; 130(6): 860-868.
Google Scholar
29
-
Kwong YL, Kim WS, Lim ST, Kim SJ, Tang T, Tse E, et al. SMILE for natural killer/T-cell lymphoma: Analysis of safety and efficacy from the Asia Lymphoma Study Group. Blood. 2012; 120: 2973-2980.
Google Scholar
30
-
Bi XW, Jiang WQ, Zhang WW, Huang JJ, Xia Y, Wang Y, et al. Treatment outcome of patients with advanced stage natural killer/T-cell lymphoma: Elucidating the effects of asparaginase and post-chemotherapeutic radiotherapy. Ann Hematol. 2015; 94: 1175-1184.
Google Scholar
31
Most read articles by the same author(s)
-
Zineb Kabala,
Mouna Bourhafour,
Tarik Chekrine,
Zineb Bouchbika,
Nadia Benchekroun,
Hassan Jouhadi,
Nezha Tawfiq,
Abdallah Badou,
Souha Sahraoui,
Epithelial Ovarian Cancer: Microenvironment and Immunecheck Point Inhibitors , European Journal of Medical and Health Sciences: Vol. 5 No. 5 (2023) -
Meriem Ait Alla,
Tarik Chekrine,
Zineb Bouchbika,
Nadia Benchakroun,
Hassan Jouhadi,
Nezha Tawfiq,
Ibtissam Rezzouki,
Mehdi Karkouri,
Hakim Lakhdar,
Souha Sahraoui,
Glioblastoma in a Patient with Neurofibromatosis Type 1: A Case Report and Literature Review , European Journal of Medical and Health Sciences: Vol. 5 No. 5 (2023) -
Ghita Hatim,
Tarik Chekrine,
Majdouline Houjami ,
Sofia Karami,
Zineb Bouchbika,
Nadia Benchakroun,
Hassan Jouhadi,
Nezha Tawfiq,
Said Hilmani,
Mehdi Karkouri,
Abdelhakim Lakhdar,
Abdelatif Benider,
Souha Sahraoui,
Adult's Medulloblastoma , European Journal of Medical and Health Sciences: Vol. 4 No. 5 (2022) -
Hatim Talib,
Tarik Chekrine,
Mouna Bourhafour,
Hassan Jouhadi,
Zineb Bouchbika,
Nadia Benchakroun,
Nezha Tawfiq,
Souha Sahraoui,
Sebaceous Carcinoma of the Eyelid: A Case Report and Review of the Literature , European Journal of Medical and Health Sciences: Vol. 4 No. 6 (2022) -
E. Ghali Benjelloun,
Ghita Hatim,
Hassan Jouhadi,
Tarik Chekrine,
Zineb Bouchbika,
Nadia Benchakroun,
Nezha Tawfik,
Mehdi Karkouri,
Abdelatif Benider,
Souha Sahraoui,
Case Report: Adult Pure Yolk Sac Tumor of the Testis , European Journal of Medical and Health Sciences: Vol. 4 No. 5 (2022) -
E. Ghali Benjelloun,
Ghita Hatim,
Zaouit Meryem,
Ibtissam Razzouki,
Nisrine Bennani Guérisse,
Hassan Jouhadi,
Tarik Chekrine,
Zineb Bouchbika,
Nadia Benchekroun,
Nezha Tawfiq,
Abdelatif Benider,
Souha Sahraoui,
Case Report: Adult Retroperitoneal Rhabdomyosarcoma , European Journal of Medical and Health Sciences: Vol. 4 No. 6 (2022) -
Zineb Kabala,
Mouna Bourhafour,
Tarik Chekrine,
Zineb Bouchbika,
Nadia Benchakroun,
Hassan Jouhadi,
Nezha Tawfiq,
Abdallah Badou,
Souha Sahraoui,
Evolutionary Profil of Triple-Negative Breast Cancer and Influence of Histopronostic Factors: Experience of Oncology Department Chu Ibn Rochd Casablanca , European Journal of Medical and Health Sciences: Vol. 5 No. 6 (2023)