Pakistan Kidney and Liver Institute and Research Centre, Pakistan
* Corresponding author
Pakistan Kidney and Liver Institute and Research Centre, Pakistan
Pakistan Kidney and Liver Institute and Research Centre, Pakistan
Avalon University School of Medicine, USA
SRM Medical College Hospital and Research Centre, India
Ankara Yildirim Beyazit University, Turkey
Bahawal Victoria Hospital, Pakistan
Quaid-e-Azam Medical College, Pakistan

Article Main Content

CKD-5 treatment is expensive and inaccessible for the majority of the Pakistani population. QOL is a valuable research tool in assessing the outcome of therapeutic interventions in chronic diseases. Unfortunately, there is no information available on the QOL in CKD-5 patients in Pakistan. In this present study, we sought to compare the difference between the quality of life in hemodialysis patients and kidney transplant recipients. The study was conducted on hemodialysis patients and kidney transplant recipients at Pakistan Kidney and Liver Institute and Research Centre (PKLI&RC). The study subjects were selected by Convenient Sampling. A comparative study was done to assess the HRQOL between hemodialysis and renal transplant recipients. The Urdu version of the WHOQOL-BREF was used. The mean score of items within all 4 domains was used to calculate the domain score. Descriptive analysis included calculation of frequency, percentage and mean for presentation of socio-demographic and WHOQOL-BREF scores in hemodialysis patients and kidney transplant recipients. The sociodemographic characteristics were significantly different between the two groups. KTRs were younger than HD patients and were generally more educated. A larger number of people in the hemodialysis group as compared to those in the KTR group were found to be unemployed. Patients in KTR group had a much better perception of quality of life (77.5 vs 58) and health (85 vs 63.5) as compared to the hemodialysis patients. KTRs had significantly higher HRQOL scores than HD patients in all 4 domains with the greatest difference seen in physical domain. KTRs also reported fewer ER visits and hospitalizations. The QOL scores of KTRs were better than hemodialysis patients in all four domains: Physical, psychological, social relationship, environmental health. Hence, renal transplant services should be encouraged for people with ESRD and should be made easily available to patients.

References

  1. Iqbal MS, Iqbal Q, Iqbal S, Ashraf S. Hemodialysis as long term treatment: Patients satisfaction and its impact on quality of life. Pakistan Journal of Medical Sciences. 2021; 37(2): 398.
    DOI  |   Google Scholar
  2. Khadka R, Basnet NB, Kafle RK. Nutritional status of out-patient hemodialysis patients in a hospital-based hemodialysis centre in Nepal. Nepalese Medical Journal. 2018; 1(1): 12-16.
    DOI  |   Google Scholar
  3. Fox E, Peace K, Neale TJ, Morrison RB, Hatfield PJ, Mellsop G. “Quality of life” for patients with end-stage renal failure. Renal Failure. 1991; 13(1): 31-35.
    DOI  |   Google Scholar
  4. Edgell ET, Coons SJ, Carter WB, Kallich JD, Mapes D, Damush TM, et al. A review of health-related quality-of-life measures used in end-stage renal disease. Clinical Therapeutics. 1996; 18(5): 887-938.
    DOI  |   Google Scholar
  5. Testa MA, Simonson DC. Assessment of quality-of-life outcomes. New England Journal of Medicine. 1996; 334(13): 835-840.
    DOI  |   Google Scholar
  6. Gerasimoula K, Lefkothea L, Maria L, Victoria A, Paraskevi T, Maria P. Quality of life in hemodialysis patients. Materia Socio-Medica. 2015; 27(5): 305.
    DOI  |   Google Scholar
  7. Pei M, Aguiar R, Pagels AA, Heimbürger O, Stenvinkel P, Bárány P, et al. Health-related quality of life as predictor of mortality in end-stage renal disease patients: an observational study. BMC Nephrology. 2019; 20(1): 1-0.
    DOI  |   Google Scholar
  8. Muehrer RJ, Becker BN. Psychosocial factors in patients with chronic kidney disease: life after transplantation: new transitions in quality of life and psychological distress. Seminars in Dialysis. 2005; 18(2): 124-131.
    DOI  |   Google Scholar
  9. Molnar-Varga M, Molnar MZ, Szeifert L, Kovacs AZ, Kelemen A, Becze A, et al. Health-related quality of life and clinical outcomes in kidney transplant recipients. American Journal of Kidney Diseases. 2011; 58(3): 444-452.
    DOI  |   Google Scholar
  10. Unruh ML, Hess R. Assessment of health-related quality of life among patients with chronic kidney disease. Advances in Chronic Kidney Disease. 2007; 14(4): 345-352.
    DOI  |   Google Scholar
  11. Rizvi SA, Naqvi SA. Renal replacement therapy in Pakistan. Saudi Journal of Kidney Diseases and Transplantation. 1996; 7(4): 404.
     Google Scholar
  12. Khan MN, Akhter MS, Ayub M, Alam S, Laghari NU. Translation and validation of quality of life scale, the brief version. Journal of the College of Physicians and Surgeons-Pakistan: JCPSP. 2003; 13(2): 98-100.
     Google Scholar