Positive Expression of 3-Nitrotyrosine in The Amniotic Membrane as A Risk Factor for Preterm Labor



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Submitted Jul 13, 2022
Published Feb 28, 2023
10.24018/ejmed.2023.5.1.1428

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Oxidative stress is a risk factor for preterm labor. 3-Nitrotyrosine is a marker of oxidative stress that can be found in the amniotic membrane. This study was conducted with the aim of understanding the pathophysiology of preterm labor for screening and management of preterm labor and its impact. This study was conducted by collecting patients with preterm pregnancies as samples and term delivery as controls who came to the delivery room of the ER Obstetrics and Gynecology Hospital Prof. Dr. I.G.N.G. Ngoerah Denpasar and Network Hospital of Udayana University in the period from November 2020 to February 2021. This is an analytical study using a case control design. Based on the analysis, there was a statistically significant difference (p < 0.001) between the case and control groups. The group of patients with positive 3-NT expression had an 8.31 times chance of experiencing preterm delivery compared to the group of patients with negative 3-NT expression.

Keywords: preterm birth 3-nitrotyrosine

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